IMMUNOHISTOCHEMICAL DEMONSTRATION OF ALPHAB-CRYSTALLIN IN HAMARTOMAS OF TUBEROUS SCLEROSIS

被引：0
|
作者：
IWAKI, T [1 ]
TATEISHI, J [1 ]
机构：
[1] KYUSHU UNIV,FAC MED,INST NEUROL,DEPT NEUROPATHOL,FUKUOKA 812,JAPAN
来源：
AMERICAN JOURNAL OF PATHOLOGY | 1991年 / 139卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of alpha-B-crystallin. Positive immunoreactions were detected in the harmartomas of various organs. Abnormal expression of alpha-B-crystallin in the hamartomas in conjunction with the alpha-B-crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of alpha-B-crystallin gene expression.
引用
收藏
页码：1303 / 1308
页数：6
相关论文
共 50 条
  • [1] TUBEROUS SCLEROSIS VARIANT WITH PRODUCTION OF ROSENTHAL FIBERS (ALPHAB-CRYSTALLIN) - CASE-5
    KUPSKY, WJ
    FROSCH, M
    PEDIATRIC PATHOLOGY, 1993, 13 (06): : 869 - 873
  • [2] Genetic variation of alpha B-crystallin (CRYAB) and CSF alphaB-crystallin in patients with multiple sclerosis
    Stoevring, B
    Frederiksen, J
    Vang, O
    Christiansen, M
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S158 - S158
  • [3] Immunohistochemical expression of Hsp27 and alphaB-crystallin in different histological subtypes of lung cancer
    Marinova, Dora
    Slavova, Yanina
    Titorenkov, Plamen
    Maksimov, Vladimir
    Trifonova, Nedka
    Djambazov, Vladimir
    Tafradjiiska, Maja
    Petrov, Danail
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [4] AlphaB-crystallin, a novel marker for breast cancer metastasis
    Lev, CD
    Kluger, HM
    Rimm, DL
    Price, JE
    BREAST CANCER RESEARCH AND TREATMENT, 2003, 82 : S91 - S91
  • [5] Novel mutations in the molecular chaperone alphaB-Crystallin cause cardiomyopathies
    Stoevring, Birgitte
    Andersen, Paal S.
    Havndrup, Ole
    Bundgaard, Henning
    Mckenna, William J.
    Christiansen, Michael
    CIRCULATION, 2006, 114 (18) : 306 - 306
  • [6] Microarray analysis of alphaA and alphaB-crystallin knockout mouse lenses
    Aryankalayi, MJ
    Carper, DA
    Brown, K
    Stephan, DA
    Wawrousek, EF
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U325 - U325
  • [7] AlphaB-crystallin and breast cancer: role and possible therapeutic strategies
    Daniela Caporossi
    Attilio Parisi
    Cristina Fantini
    Elisa Grazioli
    Claudia Cerulli
    Ivan Dimauro
    Cell Stress and Chaperones, 2021, 26 : 19 - 28
  • [8] Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing
    Mineva, I
    Gartner, W
    Hauser, P
    Kainz, A
    Löffler, M
    Wolf, G
    Oberbauer, R
    Weissel, M
    Wagner, L
    CELL STRESS & CHAPERONES, 2005, 10 (03): : 171 - 184
  • [9] AlphaB-crystallin accumulation in cerebral neurons of Alzheimer's disease
    Mao, JJ
    Katayama, S
    Harada, Y
    Watanabe, C
    Noda, K
    Ohishi, H
    Yamamura, Y
    Nakamura, S
    BRAIN PATHOLOGY, 2000, 10 (04) : 512 - 513
  • [10] AlphaB-crystallin regulates remyelination after peripheral nerve injury
    Lim, Erin-Mai F.
    Nakanishi, Stan T.
    Hoghooghi, Vahid
    Eaton, Shane E. A.
    Palmer, Alexandra L.
    Frederick, Ariana
    Stratton, Jo A.
    Stykel, Morgan G.
    Whelan, Patrick J.
    Zochodne, Douglas W.
    Biernaskie, Jeffrey
    Ousman, Shalina S.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (09) : E1707 - E1716
12345