SERUM SECRETORY IGA AND IGM AND FREE SECRETORY COMPONENT IN IGA NEPHROPATHY

被引：13

作者：

MOLE, CM

RENOULT, E

BENE, MC

SEILLES, E

KESSLER, M

REVILLARD, JP

FAURE, GC

机构：

[1] CHU NANCY,FAC MED,IMMUNOL LAB,GRIP,JEUNE EQUIPE DRED 251,VANDOEUVRE NANCY,FRANCE

[2] CHU NANCY,SERV NEPHROL,VANDOEUVRE NANCY,FRANCE

[3] FAC MED & PHARM BESANCON,IMMUNOL LAB,BESANCON,FRANCE

[4] HOP EDOUARD HERRIOT,INSERM,U80,LYON,FRANCE

来源：

NEPHRON | 1995年 / 71卷 / 01期

关键词：

ENZYME-LINKED IMMUNOSORBENT ASSAY; IGA NEPHROPATHY; POLYMERIC IMMUNOGLOBULIN RECEPTOR; SECRETORY COMPONENT; SECRETORY IMMUNOGLOBULINS;

D O I：

10.1159/000188677

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

IgA nephropathy (IgAN) is characterized by the presence of IgA and C3 deposits in the mesangium. Mesangial IgA is mostly dimeric IgA1 with a J chain, lacking a secretory component. In view of the recent demonstration of elevated serum levels of secretory component and secretory IgA in liver disease and HIV infection associated with hyper-IgA, we measured the serum secretory component in 50 IgAN patients and 45 controls. Free secretory component and secretory IgA and IgM levels were determined by enzyme-linked immunosorbent assay. Normal or low levels were found in IgAN patients. These data support previous work suggesting that in IgAN circulating and probably mesangial IgA do not originate from the epithelial compartment of the mucosal immunoglobulins as it is the case in other hyper-IgA diseases.

引用

页码：75 / 78

页数：4

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