LEGIONELLA-PNEUMOPHILA REPLICATES WITHIN RAT ALVEOLAR EPITHELIAL-CELLS

被引:54
|
作者
MODY, CH
PAINE, R
SHAHRABADI, MS
SIMON, RH
PEARLMAN, E
EISENSTEIN, BI
TOEWS, GB
机构
[1] UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 4N1,AB,CANADA
[2] UNIV CALGARY,FOOTHILLS HOSP,CALGARY,AB,CANADA
[3] UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109
[4] UNIV MICHIGAN,DEPT MICROBIOL,ANN ARBOR,MI 48109
来源
JOURNAL OF INFECTIOUS DISEASES | 1993年 / 167卷 / 05期
关键词
D O I
10.1093/infdis/167.5.1138
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Legionella pneumophila replicates in the distal pulmonary airspace, causing legionnaires' pneumonia. Legionella organisms replicate within alveolar macrophages and recruited blood monocytes; however, when these cells are activated, they become potent inhibitors of L. pneumophila proliferation. L. pneumophila may replicate in other cells and thereby avoid the host defenses of macrophages. Experiments demonstrated that L. pneumophila replicate within primary cultures of rat pulmonary alveolar epithelial cells. Double-label immunofluorescent and electron microscopy demonstrated L. pneumophila within epithelial cells. Replication of L. pneumophila required similar numbers of alveolar epithelial cells or alveolar macrophages, required viable epithelial cells, and took place intracellularly. While replication of L. pneumophila occurred in both serum-free and serum-containing media, it was enhanced in the presence of serum. Pulmonary alveolar epithelial cells may represent an alternative site for replication of Legionella species in the terminal airspace and thus clarify some previously unexplained aspects of the pathogenesis of legionnaires' disease.
引用
收藏
页码:1138 / 1145
页数:8
相关论文
共 50 条
  • [21] IFN-GAMMA-ACTIVATED HUMAN ALVEOLAR MACROPHAGES INHIBIT THE INTRACELLULAR MULTIPLICATION OF LEGIONELLA-PNEUMOPHILA
    NASH, TW
    LIBBY, DM
    HORWITZ, MA
    JOURNAL OF IMMUNOLOGY, 1988, 140 (11): : 3978 - 3981
  • [22] ESCHERICHIA-COLI F PLASMID TRANSFERS TO AND REPLICATES WITHIN LEGIONELLA-PNEUMOPHILA - AN ALTERNATIVE TO USING AN RP4-BASED SYSTEM FOR GENE DELIVERY
    WIATER, LA
    MARRA, A
    SHUMAN, HA
    PLASMID, 1994, 32 (03) : 280 - 294
  • [23] TREATMENT OF ALVEOLAR MACROPHAGES WITH CYTOCHALASIN-D INHIBITS UPTAKE AND SUBSEQUENT GROWTH OF LEGIONELLA-PNEUMOPHILA
    ELLIOTT, JA
    WINN, WC
    INFECTION AND IMMUNITY, 1986, 51 (01) : 31 - 36
  • [24] Invasion of Lung Epithelial Cells By Filamentous Legionella pneumophila
    Prashar, A.
    Duncan, C.
    Bhatia, S.
    Low, D. E.
    Garduno, R. A.
    Guyard, C.
    Terebiznik, M.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [25] Invasion of Polarized Epithelial Cells by Filamentous Legionella Pneumophila
    Tabatabaeiyazdi, Z.
    Prashar, A.
    Duncan, C.
    Guyard, C.
    Terebiznik, M.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [26] TISSUE FACTOR PROCOAGULANT EXPRESSION BY RAT ALVEOLAR EPITHELIAL-CELLS
    GROSS, TJ
    SIMON, RH
    SITRIN, RG
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 6 (04) : 397 - 403
  • [27] ARACHIDONIC-ACID METABOLISM BY RAT ALVEOLAR EPITHELIAL-CELLS
    CHAUNCEY, JB
    PETERSGOLDEN, M
    SIMON, RH
    LABORATORY INVESTIGATION, 1988, 58 (02) : 133 - 140
  • [28] HYDROGEN-ION CURRENTS IN RAT ALVEOLAR EPITHELIAL-CELLS
    DECOURSEY, TE
    BIOPHYSICAL JOURNAL, 1991, 60 (05) : 1243 - 1253
  • [29] MECHANISMS OF POTASSIUM CHANNEL BLOCK IN RAT ALVEOLAR EPITHELIAL-CELLS
    JACOBS, ER
    DECOURSEY, TE
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1990, 255 (02): : 459 - 472
  • [30] CHARACTERIZING MUTAGENESIS IN THE HPRT GENE OF RAT ALVEOLAR EPITHELIAL-CELLS
    DRISCOLL, KE
    DEYO, LC
    HOWARD, BW
    POYNTER, J
    CARTER, JM
    EXPERIMENTAL LUNG RESEARCH, 1995, 21 (06) : 941 - 956