The Epigenetics of Gastrointestinal Malignancies

被引：2
|
作者：
Hasanali, Zainul [1 ]
Stuart, August [1 ]
Yee, Nelson [2 ]
Sharma, Kamal [3 ]
Epner, Elliot [2 ]
机构：
[1] Penn State Hershey Canc Inst, Expt Therapeut A CH74, Hershey, PA 17033 USA
[2] Penn State Hershey Canc Inst, Div Hematol Oncol, 500 Univ Dr,POB 850, Hershey, PA 17033 USA
[3] Penn State Hershey Canc Inst, Hershey, PA 17033 USA
来源：
CURRENT COLORECTAL CANCER REPORTS | 2012年 / 8卷 / 04期
关键词：
Gastrointestinal cancer; Epigenetics; Cladribine; Vorinostat; Cetuximab; DNA methylation; Histone acetylation; Colorectal; Pancreatic;
D O I：
10.1007/s11888-012-0147-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.
引用
收藏
页码：254 / 262
页数：9
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