THE APPLICATIONS OF NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY TO THE ANALYSIS OF POLYMORPHIC FORMS OF CIMETIDINE

被引：39
|
作者：
TUDOR, AM
DAVIES, MC
MELIA, CD
LEE, DC
MITCHELL, RC
HENDRA, PJ
CHURCH, SJ
机构：
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,WELWYN AL6 9AR,WALES
[3] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND
[4] COURTAULDS RES,COVENTRY CV6 5RS,ENGLAND
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 1991年 / 47卷 / 9-10期
关键词：
D O I：
10.1016/0584-8539(91)80229-C
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Fourier transform (FT)-Raman spectroscopy, utilizing a near-infrared (Nd: YAG laser, at 1.064-mu-m) source was used to characterise the three anhydrous polymorphic forms A, B and C of the drug cimetidine (N"-cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl) methylthio]ethyl]guanidine). The FT-Raman spectra were free from fluorescence interference and had good signal-to-noise ratios. Each polymorph has a distinct spectrum, characterised by two regions, 1250-1050 cm-1 and 1500-1350 cm-1. This work demonstrates that it is possible to use FT-Raman spectroscopy to differentiate between polymorphic forms of the same compound.
引用
收藏
页码：1389 / 1393
页数：5
相关论文
共 50 条
  • [11] NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY - FACING ABSORPTION AND BACKGROUND
    SCHRADER, B
    HOFFMANN, A
    KELLER, S
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1991, 47 (9-10): : 1135 - 1148
  • [12] FOURIER-TRANSFORM RAMAN-SPECTROSCOPY OF PHOTOACTIVE PROTEINS WITH NEAR-INFRARED EXCITATION
    JOHNSON, CK
    RUBINOVITZ, R
    APPLIED SPECTROSCOPY, 1990, 44 (07) : 1103 - 1106
  • [13] SURFACE-ENHANCED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY IN THE NEAR-INFRARED
    CROOKELL, A
    FLEISCHMANN, M
    HANNIET, M
    HENDRA, PJ
    CHEMICAL PHYSICS LETTERS, 1988, 149 (02) : 123 - 127
  • [14] NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY IN HUMAN LENS RESEARCH
    NIE, SM
    BERGBAUER, KL
    KUCK, JFR
    YU, NT
    EXPERIMENTAL EYE RESEARCH, 1990, 51 (05) : 619 - 623
  • [15] A COMPARISON OF FOURIER-TRANSFORM INFRARED AND NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY FOR QUANTITATIVE MEASUREMENTS - AN APPLICATION IN POLYMORPHISM
    DEELEY, CM
    SPRAGG, RA
    THRELFALL, TL
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1991, 47 (9-10): : 1217 - 1223
  • [16] FOURIER-TRANSFORM INFRARED AND FOURIER-TRANSFORM RAMAN-SPECTROSCOPY OF POLYMERS - PRINCIPLES AND APPLICATIONS
    URBAN, MW
    ADVANCES IN CHEMISTRY SERIES, 1993, (236): : 3 - 40
  • [17] APPLICATION OF NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY IN MEDICAL-RESEARCH
    KELLER, S
    SCHRADER, B
    HOFFMANN, A
    SCHRADER, W
    METZ, K
    REHLAENDER, A
    PAHNKE, J
    RUWE, M
    BUDACH, W
    JOURNAL OF RAMAN SPECTROSCOPY, 1994, 25 (7-8) : 663 - 671
  • [18] CHARACTERIZATION OF POLYMORPHIC FORMS OF FLUCONAZOLE USING FOURIER-TRANSFORM RAMAN-SPECTROSCOPY
    GU, XJ
    JIANG, W
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (12) : 1438 - 1441
  • [19] STRUCTURAL-ANALYSIS OF PIGEON LENS CRYSTALLINS BY NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY
    CHIOU, SH
    CHEN, WL
    BIOCHEMISTRY INTERNATIONAL, 1992, 28 (03): : 401 - 412
  • [20] APPLICATIONS OF NEAR-INFRARED FOURIER-TRANSFORM RAMAN SPECTROMETRY
    WRIGHT, NA
    KRISHNAN, K
    7TH INTERNATIONAL CONFERENCE ON FOURIER TRANSFORM SPECTROSCOPY, 1989, 1145 : 186 - 187
12345