THE APPLICATIONS OF NEAR-INFRARED FOURIER-TRANSFORM RAMAN-SPECTROSCOPY TO THE ANALYSIS OF POLYMORPHIC FORMS OF CIMETIDINE

被引：39
|
作者：
TUDOR, AM
DAVIES, MC
MELIA, CD
LEE, DC
MITCHELL, RC
HENDRA, PJ
CHURCH, SJ
机构：
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,WELWYN AL6 9AR,WALES
[3] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND
[4] COURTAULDS RES,COVENTRY CV6 5RS,ENGLAND
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 1991年 / 47卷 / 9-10期
关键词：
D O I：
10.1016/0584-8539(91)80229-C
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Fourier transform (FT)-Raman spectroscopy, utilizing a near-infrared (Nd: YAG laser, at 1.064-mu-m) source was used to characterise the three anhydrous polymorphic forms A, B and C of the drug cimetidine (N"-cyano-N-methyl-N'-[2-[(5-methyl-1H-imidazol-4-yl) methylthio]ethyl]guanidine). The FT-Raman spectra were free from fluorescence interference and had good signal-to-noise ratios. Each polymorph has a distinct spectrum, characterised by two regions, 1250-1050 cm-1 and 1500-1350 cm-1. This work demonstrates that it is possible to use FT-Raman spectroscopy to differentiate between polymorphic forms of the same compound.
引用
收藏
页码：1389 / 1393
页数：5
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