The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism

被引：52

作者：

Cuevas-Ramos, Daniel ^{[1
]}

Almeda-Valdes, Paloma ^{[1
]}

Aguilar-Salinas, Carlos A. ^{[1
]}

Cuevas-Ramos, Gabriel ^{[2
]}

Cuevas-Sosa, Andres A. ^{[3
]}

Gomez-Perez, Francisco J. ^{[1
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Vasco Quiroga 15,Secc XVI, Mexico City 14000, DF, Mexico

[2] Ecole Natl Veterinaire Toulouse, Toulouse, France

[3] Centro Invest Psicoanal & Psicoterapia, Mexico City, DF, Mexico

来源：

CURRENT DIABETES REVIEWS | 2009年 / 5卷 / 04期

关键词：

Fibroblast growth factor 21; Glucose; Energy balance; Insulin; Metabolic syndrome; Type 2 diabetes mellitus;

D O I：

10.2174/157339909789804396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FGF21 is a novel member of the FGFs family, is mainly expressed in liver and it functions as a potent activator of glucose uptake on adipocytes. When over expressed in transgenic mice, it protects animals from diet-induced obesity and its administration to diabetic rodents and monkeys lowers blood glucose and triglyceride levels. Recently, increased levels of FGF21 have been identified as an independent risk factor related with metabolic syndrome. A review of the relevant roles of FGF21 in metabolism is presented here.

引用

页码：216 / 220

页数：5

共 50 条

[21] The crosstalk between fibroblast growth factor 21 (FGF21) system and substance use
Wang, Tammy
Tyler, Ryan E.
Ilaka, Oyenike
Cooper, Diane
Farokhnia, Mehdi
Leggio, Lorenzo
ISCIENCE, 2024, 27 (07)
[22] Fibroblast Growth Factor 21 (FGF21) in Children and Adolescents With Chronic Kidney Disease
Gamrot, Zuzanna
Adamczyk, Piotr
Swietochowska, Elzbieta
Roszkowska-Bjanid, Dagmara
Garrrot, Jakub
Szczepanska, Maria
PHYSIOLOGICAL RESEARCH, 2020, 69 (03) : 451 - 460
[23] Fibroblast Growth Factor 21 (FGF21) protein levels in the placenta of macrosomic infants
Harrison, Rachel
Allen, Katherine
Naatz, Aaron
Corbett, John
Cruz, Meredith
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 222 (01) : S337 - S338
[24] Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Min, Xiaoshan
Weiszmann, Jennifer
Johnstone, Sheree
Wang, Wei
Yu, Xinchao
Romanow, William
Thibault, Stephen
Li, Yang
Wang, Zhulun
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (38) : 14678 - 14688
[25] How a metabolic hormone, FGF21 (fibroblast growth factor 21) impacts reproduction
Bourdon, Guillaume
Froment, Pascal
Ducluzeau, Pierre Henri
M S-MEDECINE SCIENCES, 2021, 37 (03): : 265 - 270
[26] The Mechanistic Role of Fibroblast Growth Factor 21 (FGF21) in Growth Hormone Resistance Secondary to Chronic Childhood Conditions
Mistry, Jayna
Ruiz-Babot, Gerard
Guasti, Leonardo
Dunkel, Leo
HORMONE RESEARCH IN PAEDIATRICS, 2016, 86 : 362 - 362
[27] Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism
Sun, Mark Y.
Yoo, Eunjong
Green, Brenda J.
Altamentova, Svetlana M.
Kilkenny, Dawn M.
Rocheleau, Jonathan V.
BIOPHYSICAL JOURNAL, 2012, 103 (11) : 2379 - 2388
[28] Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
Domouzoglou, Eleni M.
Naka, Katerina K.
Vlahos, Antonios P.
Papafaklis, Michail I.
Michalis, Lampros K.
Tsatsoulis, Agathoklis
Maratos-Flier, Eleftheria
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2015, 309 (06): : H1029 - H1038
[29] Fibroblast Growth Factor 21 (FGF21) in NAFLD: From a Biomarker to a Therapeutic Target.
Gallego-Duran, Rocio
Martin-Bermudo, Francisco
Ampuero, Javier
Pastor-Ramirez, Helena
Montero-Vallejo, Rocio
Alvarez-Amor, Leticia
Gil-Gomez, Antonio
de los Angel Rojas, Maria
Maya, Douglas
Andreola, Fausto
Jalan, Rajiv
Romero-Gomez, Manuel
HEPATOLOGY, 2018, 68 : 1014A - 1014A
[30] Placental Fibroblast Growth Factor 21 (FGF21) mRNA but Not Protein Expression Is Increased in Preeclampsia
Romero, Katherin Scholz
Barrett, Helen L.
Kubala, Marta H.
McIntyre, Harold David
Callaway, Leonie K.
Nitert, Marloes Dekker
ENDOCRINE REVIEWS, 2014, 35 (03)

← 1 2 3 4 5 →