GLYCOSIDATION OF SIALIC-ACID

被引：160
|
作者：
OKAMOTO, K [1 ]
GOTO, T [1 ]
机构：
[1] NAGOYA UNIV,FAC AGR,ORGAN CHEM LAB,NAGOYA,AICHI 464,JAPAN
来源：
TETRAHEDRON | 1990年 / 46卷 / 17期
关键词：
D O I：
10.1016/S0040-4020(01)87911-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sialic acid is located at the non-reducing ends of carbohydrate chains of glycoproteins and glycolipids and plays an important role in biological processes. The synthesis of sialylated oligosaccharides has been encouraged in order to clarify their vital functions. In the synthesis of sialylated oligosaccharides, the most difficult problem remaining is the stereoselective glycosidation of sialic acid by the creation of the α-glycosidic linkage. This Report discusses enzymic and synthetic approaches to the glycosidation of sialic acid by new methodologies. © 1990.
引用
收藏
页码：5835 / 5857
页数：23
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