Using MRI neuroimaging methods to detect treatment responses in Alzheimer's disease

The rapid development of neuroimaging outcome measures for monitoring treatment effects and disease progression in neurological disorders presents both opportunities and hazards. An overview of functional MRI studies of regional brain activation using cognitive activation and resting state paradigms in mild cognitive impairment and Alzheimer's disease indicates that this method can detect group treatment responses in the absence of overt behavioral change, as well as the kinetic and dynamic effects of the available symptomatic treatment compounds. Structural and spectroscopic MRI methods offer the prospect of objective and clinically meaningful assessment of progressive neuropathological changes and their modification through intervention. Including imaging parameters adequately powers small group studies of drug effects with additional advantages for more robust patient characterization and staging. These techniques should play an increasingly important role at an earlier stage of treatment evaluation, but the need for expert implementation and analysis means that clinical applications in individual cases are still in development.