A PREDICATIVE MODEL FOR CERTAIN DIRECTED METALATIONS .1. APPLICATIONS TO THE BEHAVIOR OF ANISOLE

被引：27
|
作者：
SLOCUM, DW [1 ]
MOON, R [1 ]
THOMPSON, J [1 ]
COFFEY, DS [1 ]
LI, JD [1 ]
SLOCUM, MG [1 ]
SIEGEL, A [1 ]
GAYTONGARCIA, R [1 ]
机构：
[1] INDIANA STATE UNIV,DEPT CHEM,TERRE HAUTE,IN 47809
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期
关键词：
D O I：
10.1016/0040-4039(94)85060-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A model whereby the relative ability of the methoxy group to direct metalations in aromatic systems is described. Evidence is presented for a dramatic acceleration of the rate of metalation of anisole provided by the presence of TMEDA resulting in the largest yield of ortho-metalation (>95%) heretofore reported. Lastly, significant acceleration of the rate; of metalation of anisole has been found using a catalytic amount of TMEDA.
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页码：385 / 388
页数：4
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