Synthesis, Characterization and Biological Activities of Pyrimido and Mercaptopyrimidocycloocta[b] indole Derivatives.

A resourceful method for the synthesis and study of biological activity of eight membered indole fused compounds analog to pyrimidine derivatives of natural product. With the precursor cycloocta[b] indole, which was prepared by the reported method, 4-methyl-benzaldehyde is supposed to condense and to give condensed product namely, 2-(4'-methyl)-benzylidene-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b] indole (3). Further compounds were prepared namely, pyrimidocycloocta[b] indole and merceptopyrimidocycloocta[b] indole derivatives by allowing the appropriate condensed product to react with urea and thiourea, which results in the formation of 2-hydroxy-4-(4'-methyl)-phenyl-5,6,7,8tetrahydropyrimido[ 5', 6': 7,8] cycloocta[b] indoles (4) and 2-mercapto-4-(4'-methyl)-phenyl-5,6,7,8tetrahydropyrimido[ 5', 6': 7,8] cycloocta[b] indoles (5) respectively. Biological activities for the synthesized compounds were studied against bacterial and fungal strains which show moderate potency of the prepared compounds.