EFFICIENT REGIOSPECIFIC SYNTHESIS OF 2 CYTOTOXIC FURONAPHTHOQUINONES, 5,7-DIMETHOXY-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-4,9-DIONE AND 5,6,7-TRIMETHOXY-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-4,9-DIONE

被引：18
|
作者：
PERRY, PJ
PAVLIDIS, VH
HADFIELD, JA
COUTTS, IGC
机构：
[1] CHRISTIE HOSP NATL HLTH SERV TRUST, PATERSON INST CANC RES, CRC, DEPT EXPTL CHEMOTHERAPY, MANCHESTER M20 9BX, LANCS, ENGLAND
[2] NOTTINGHAM TRENT UNIV, DEPT PHYS SCI, NOTTINGHAM NG11 8NS, ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 09期
关键词：
D O I：
10.1039/p19950001085
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Following the recent isolation of several furonaphthoquinones from two Latana species (Verbenaceae), a novel synthetic method for the preparation of two cytotoxic furonaphthoquinones, 5,7-dimethoxy-4,9-dihydronaphtho[2,3-b]furan-4,9-dione 8a and 5,6,7-trimethoxy-4,9-dihydronaphtho[2,3-b]furan-4,9-dione is described. The title compounds were obtained in high overall yield via hydrogen peroxide oxidation of intermediate 4-hydroxy-9-trifluoroacetylnaphthofurans. Both the title compounds exhibit cytotoxic activity towards three mammalian cell lines (2.99-6.6 mu mol dm(-3)).
引用
收藏
页码：1085 / 1087
页数：3
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