Short-step synthesis of 1,3-disubstituted naphtho[2,3-c]furan-4,9-dione and naphtho[2,3-b]furan-4,9-dione by the Friedel-Crafts reaction

被引：5
|
作者：
Koyama, J [1 ]
Toyokuni, I [1 ]
Kino, A [1 ]
Tagahara, K [1 ]
机构：
[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan
来源：
HETEROCYCLES | 1998年 / 48卷 / 08期
关键词：
D O I：
10.3987/COM-98-8172
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,3-Dialkylnaphtho[2,3-c] furan-4,9-diones were obtained by the Friedel-Crafts reaction of phthalic anhydride with 2,5-dialkylfurans. The reaction of phthalic anhydride with 2-acetyl-5-methylfuran, instead of 2,5-dialkylfurans, produced 2-methylnaphtho[2,3-b] furan-4,9-dione. The application of this method to the synthesis of 8-hydroxynaphtho [2, 3-b] furan-4, 9-dione [isodiodantunezone] is also described.
引用
收藏
页码：1631 / 1638
页数：8
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