SPECTROPHOTOMETRIC ESTIMATION OF MONTELUKAST FROM BULK DRUG AND TABLET DOSAGE FORM

Two Simple, accurate, precise and sensitive spectrophotometric methods for estimation of Montelukast sodium (MON) have been developed and validated. The zero order spectroscopic method (Method I) and area under curve method (Method II) have developed. The proposed methods are validated according to ICH Q2B guidelines. The Montelukast sodium gives maximum absorbance at 241nm in chloroform and observed linearity 2-20 mu g/ml for zero order method and 4-20 mu g/ml for area under curve method. The stability of drug in chloroform has been studied and drug shows good stability in Chloroform. The recovery by method I and method II are 99.52 +/- 0.069, 101.93 +/- 0.11 respectively. The both spectrophotometric methods can be applied for routine analysis of Montelukast sodium in tablet formulation and in bulk drug.