Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form

被引：1

作者：

Patel, Nikita N. ^{[1
]}

Rana, Nikesh S. ^{[1
]}

Rajesh, K. S. ^{[1
]}

Patel, Parag R. ^{[1
]}

Limbachiya, Ujjaval ^{[1
]}

Pasha, T. Y. ^{[2
]}

机构：

[1] Parul Inst Pharm, Limda, Gujarat, India

[2] Parul Inst Pharm & Res, Limda, Gujarat, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2014年 / 48卷 / 02期

关键词：

Montelukast Sodium; Ebastine; Absorbance correction method; RP-HPLC;

D O I：

10.5530/ijper.48.2.12

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

A simple spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium and Ebastine from tablet dosage form. Absorbance correction method in which absorbance is measured at two wavelengths, 345 nm at which Ebastine has no absorbance and 253 nm at which both the drugs have considerable absorbance. This method was found linear between the range of 5-25 mu g/ml for Montelukast Sodium and Ebastine. The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Montelukast Sodium and Ebastine in their combined tablet dosage form.

引用

页码：87 / 91

页数：5

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