INCREASED CEREBROSPINAL-FLUID PYRUVATE LEVELS IN ALZHEIMERS-DISEASE

被引：44
|
作者：
PARNETTI, L
GAITI, A
POLIDORI, MC
BRUNETTI, M
PALUMBO, B
CHIONNE, F
CADINI, D
CECCHETTI, R
SENIN, U
机构：
[1] UNIV PERUGIA,IST BIOCHIM & CHIM MED,I-06122 PERUGIA,ITALY
[2] MONTELUCE POLICLIN,SERV FIS SANITARIA,PERUGIA,ITALY
来源：
NEUROSCIENCE LETTERS | 1995年 / 199卷 / 03期
关键词：
ALZHEIMERS DISEASE; IN VIVO BIOLOGICAL MARKERS; CEREBROSPINAL FLUID; LACTATE; PYRUVATE; CEREBRAL ENERGY METABOLISM;
D O I：
10.1016/0304-3940(95)12058-C
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Impaired energy metabolism is an early, predominant feature in Alzheimer's disease. In order to find out simple, reliable 'in vivo' markers for the clinical-biological typization of the disorder, we measured cerebrospinal fluid (CSF) glucose, lactate and pyruvate levels in patients suffering from dementia of Alzheimer type (DAT) and in healthy elderly controls. DAT group showed remarkably higher levels of pyruvate (P = 0.01), with no overlap with the values obtained in controls. CSF pyruvate levels were also significantly associated with the severity of dementia. Therefore, CSF pyruvate levels neatly separate DAT patients from controls, having also pathogenetic value.
引用
收藏
页码：231 / 233
页数：3
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