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- [30] A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan and its application to in biological matrices in vitro CYP2D6 and CYP3A4 inhibition study BIOMEDICAL CHROMATOGRAPHY, 2009, 23 (11) : 1131 - 1137