PHOSPHATIDYLCHOLINE-PHOSPHOLIPASE-C MEDIATES THE INDUCTION OF NERVE GROWTH-FACTOR IN CULTURED GLIAL-CELLS

被引：16
|
作者：
LAVIADA, ID [1 ]
BAUDET, C [1 ]
GALVEROPERH, I [1 ]
NAVEILHAN, P [1 ]
BRACHET, P [1 ]
机构：
[1] CHRU,INSERM,U298,F-49100 ANGERS,FRANCE
来源：
FEBS LETTERS | 1995年 / 364卷 / 03期
关键词：
NERVE GROWTH FACTOR; PHOSPHATIDYLCHOLINE; PROTEIN KINASE C; SPHINGOSINE; GLIAL CELL; ASTROCYTE;
D O I：
10.1016/0014-5793(95)00414-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Addition of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) to cultured glial cells increased the levels of nerve growth factor (NGF) mRNA and the amount of cell-secreted NGF, The effect of PC-PLC was 2.5 times higher than that elicited by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate. In cells in which protein kinase C (PKC) was fully inhibited or downregulated, the effect of PC-PLC was reduced - though still evident - and similar to that exerted by sphingosine. Results thus indicate that PC-PLC induces the synthesis of NGF by glial cells by a PKC-dependent and PKC-independent mechanisms.
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页码：301 / 304
页数：4
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