2-DIBENZYLAMINOBUTANE-1,4-DIOL - AN EFFECTIVE CHIRAL BUILDING-BLOCK FOR THE SYNTHESIS OF 1,2-AMINO ALCOHOLS

被引：0

作者：

GMEINER, P

KARTNER, A

机构：

来源：

SYNTHESIS-STUTTGART | 1995年 / 01期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective activation and protection of the chiral building block 1, readily available from L-aspartic acid, leads to the key intermediate 8. Employing classical nucleophiles, heterocyclic anions or organocuprates, 8 could be transformed into the displacement products 9. Finally, hydrolysis affords the homochiral 1,2-amino alcohols 4 in 48-77% yield (based on 8).

引用

页码：83 / 86

页数：4

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