ONE-DIMENSIONAL HETERONUCLEAR CHEMICAL-SHIFT CORRELATION USING CHEMICAL-SHIFT-SELECTIVE FILTERS

The technique of a chemical-shift-selective filter has been applied to the heteronuclear correlation experiment, resulting in effective selective one-dimensional correlations. The proposed method has several distinct advantages over the more common selective population-transfer techniques: a chemical-shift resolution of only a few hertz in the 1H spectrum is needed to achieve an unambiguous correlation, practically no knowledge of 1J(C, H) is required, and finally only nonselective proton pulses are used during the course of the experiment. When applied to CH, CH3 or equivalent CH2 protons this technique gives a level of sensitivity similar to that achieved in ordinary INEPT experiments. Application to nonequivalent CH2 protons is discussed in detail and a special experiment is proposed for this case. The concept of a chemical-shift-selective filter has also been applied to proton-proton-carbon relay experiments. © 1992.