Reaching out for the other end with p53-binding protein 1

被引：2
|
作者：
van Gent, Dik C. [1 ]
机构：
[1] Erasmus MC, Dept Cell Biol & Genet, Rotterdam, Netherlands
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 05期
关键词：
CLASS-SWITCH RECOMBINATION; DOUBLE-STRAND BREAKS; DNA-DAMAGE; 53BP1; REPAIR; MDC1; ATM; STABILITY; TELOMERES; P53;
D O I：
10.1016/j.tibs.2009.01.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.
引用
收藏
页码：226 / 229
页数：4
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