VIRUS-MEDIATED INDUCTION IN HUMAN-LYMPHOCYTES OF ANTIBODY-INDEPENDENT CYTO-TOXICITY (VDCC) AND ENHANCEMENT OF ANTIBODY-DEPENDENT CYTO-TOXICITY (ADCC) AGAINST NATURAL KILLER-RESISTANT TUMOR TARGET-CELLS
被引:8
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作者:
ALSHEIKHLY, AR
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ROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDENROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDEN
ALSHEIKHLY, AR
[1
]
ANDERSSON, T
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ROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDENROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDEN
ANDERSSON, T
[1
]
PERLMANN, P
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ROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDENROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDEN
PERLMANN, P
[1
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机构:
[1] ROSLAGSTULL HOSP, DEPT INFECT DIS, S-11489 STOCKHOLM, SWEDEN
The effect of Parotis virus on the in vitro cytotoxicity of human lymphocytes against NK[natural killer]-resistant mouse mastocytoma cells was studied. In the 51Cr-release assay, treatment of lymphocytes with virus induced a rapid cytotoxicity in the absence of anti-P815 antibody (virus-dependent cellular cytotoxicity, VDCC) and strongly enhanced antibody-dependent cytotoxicity (ADCC). At the effector cell level, virus treatment increased the frequency of target-binding cells (TBC) as well as the proportion thereof mediating VDCC and/or ADCC, indicating recruitment of active effector cells. The recruited cells were heterogeneous but contained a major fraction bearing the T-cell-associated antigen T3. Virus decreased rather than increased the recycling capacity of the cytotoxic lymphocytes, suggesting that VDCC induction and ADCC enhancement were due to a virus-mediated improvement of effector cell-target cell interactions. VDCC and ADCC enhancement may be of protective importance in early phases of virus infection as well as for the production of nonspecific tissue injuries associated with viral disease.
机构:
UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA
KONDO, LL
ROSENAU, W
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UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA
ROSENAU, W
WARA, DW
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UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, SCH MED, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA
WARA, DW
JOURNAL OF IMMUNOLOGY,
1981,
126
(03):
: 1131
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1133