HEADACHE IN ACROMEGALY - DRAMATIC IMPROVEMENT WITH THE SOMATOSTATIN ANALOG SMS 201-995

被引：22
|
作者：
MUSOLINO, NR [1 ]
MARINO, R [1 ]
BRONSTEIN, MD [1 ]
机构：
[1] UNIV SAO PAULO,HOSP CLIN,SCH MED,DIV FUNCT NEUROSURG,NEUROENDOCRINE UNIT,SAO PAULO,BRAZIL
来源：
CLINICAL JOURNAL OF PAIN | 1990年 / 6卷 / 03期
关键词：
D O I：
10.1097/00002508-199009000-00013
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Two acromegalic patients with severe headache, persisting after pituitary adenomectomy followed by radiotherapy in one, were treated with the somatostatin analogue SMS 201-995. Both had been resistant to conventional headache therapy and experienced dramatic and rapid relief after the first injection of the analogue. This result persisted with long-term treatment of the drug. Although the mechanism of action of SMS 201-995 in pain remains unclear, the rapid and efficacious analgesic effect of this compound may be one more indication for its use in pituitary tumors associated with cephalalgias.
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页码：243 / 245
页数：3
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