HEADACHE IN ACROMEGALY - DRAMATIC IMPROVEMENT WITH THE SOMATOSTATIN ANALOG SMS 201-995

被引：22
|
作者：
MUSOLINO, NR [1 ]
MARINO, R [1 ]
BRONSTEIN, MD [1 ]
机构：
[1] UNIV SAO PAULO,HOSP CLIN,SCH MED,DIV FUNCT NEUROSURG,NEUROENDOCRINE UNIT,SAO PAULO,BRAZIL
来源：
CLINICAL JOURNAL OF PAIN | 1990年 / 6卷 / 03期
关键词：
D O I：
10.1097/00002508-199009000-00013
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Two acromegalic patients with severe headache, persisting after pituitary adenomectomy followed by radiotherapy in one, were treated with the somatostatin analogue SMS 201-995. Both had been resistant to conventional headache therapy and experienced dramatic and rapid relief after the first injection of the analogue. This result persisted with long-term treatment of the drug. Although the mechanism of action of SMS 201-995 in pain remains unclear, the rapid and efficacious analgesic effect of this compound may be one more indication for its use in pituitary tumors associated with cephalalgias.
引用
收藏
页码：243 / 245
页数：3
相关论文
共 50 条
  • [1] TREATMENT OF ACROMEGALY WITH THE SOMATOSTATIN ANALOG SMS 201-995
    DONALD, RA
    ESPINER, EA
    CUNEO, RC
    GLUCKMAN, P
    LIVESEY, JH
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1988, 18 (02): : 137 - 142
  • [2] TREATMENT OF RESISTANT ACROMEGALY WITH A SOMATOSTATIN ANALOG (SMS 201-995)
    BARNARD, LB
    GRANTHAM, WG
    LAMBERTON, P
    JACKSON, IMD
    CLINICAL RESEARCH, 1986, 34 (02): : A641 - A641
  • [3] SUCCESSFUL TREATMENT OF OPHTHALMOPLEGIA IN ACROMEGALY WITH THE SOMATOSTATIN ANALOG SMS 201-995
    VANLIESSUM, PA
    PIETERS, GFFM
    HERMUS, ARMM
    SMALS, AGH
    KLOPPENBORG, PWC
    NETHERLANDS JOURNAL OF MEDICINE, 1988, 32 (5-6): : 289 - 292
  • [4] THERAPEUTIC EFFICACY OF A SOMATOSTATIN ANALOG (SMS 201-995) IN ACTIVE ACROMEGALY
    TOLIS, G
    YOTIS, A
    DELPOZO, E
    PITOULIS, S
    JOURNAL OF NEUROSURGERY, 1986, 65 (01) : 37 - 40
  • [5] EFFECTS OF SOMATOSTATIN ANALOG SMS 201-995
    POSTON, GJ
    GILLESPIE, J
    BRITISH JOURNAL OF SURGERY, 1990, 77 (06) : 714 - 714
  • [6] LONG-TERM TREATMENT OF ACROMEGALY WITH THE SOMATOSTATIN ANALOG SMS 201-995
    LAMBERTS, SWJ
    UITTERLINDEN, P
    VERSCHOOR, L
    VANDONGEN, KJ
    DELPOZO, E
    NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (25): : 1576 - 1578
  • [7] EFFECT OF THE SOMATOSTATIN ANALOG SMS 201-995 ON FECAL FAT EXCRETION IN ACROMEGALY
    MCGREGOR, AR
    TROUGHTON, WD
    DONALD, RA
    ESPINER, EA
    HORMONE AND METABOLIC RESEARCH, 1990, 22 (01) : 55 - 56
  • [8] TREATMENT OF ACROMEGALY WITH LONG-ACTING SOMATOSTATIN ANALOG SMS 201-995
    HORIKAWA, R
    TAKANO, K
    HIZUKA, N
    ASAKAWA, K
    SUKEGAWA, I
    HIROSE, N
    HORIBA, N
    KASONO, K
    MASUDA, A
    OHBA, Y
    NAKAGAMI, Y
    TSUSHIMA, T
    SHIZUME, K
    ENDOCRINOLOGIA JAPONICA, 1988, 35 (05): : 741 - 751
  • [9] TREATMENT OF THERAPY-RESISTANT ACROMEGALY WITH THE SOMATOSTATIN ANALOG SMS 201-995
    VONWERDER, K
    SCHOPOHL, J
    LOSA, M
    LOPEZ, JA
    MULLER, OA
    PICHL, J
    ROSENTHALER, J
    DELPOZO, E
    ACTA ENDOCRINOLOGICA, 1987, 114 : 202 - 202
  • [10] IMPROVEMENT OF PSORIASIS WITH CHRONIC USE OF SOMATOSTATIN (SMS) ANALOG 201-995
    CAMISA, C
    ODORISIO, TM
    MACEYKO, R
    MEKHJIAN, HS
    MALARKEY, WB
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 88 (04) : 480 - 480
12345