SYNTHESIS METHYL NITROPHENYL ACRYLATE AND CYTOTOXIC ACTIVITY TEST AGAINST P388 LEUKEMIA CELLS

被引：4
|
作者：
Ernawati, Teni [1 ]
Khoirunni'mah, Zulfa [2 ]
机构：
[1] Indonesian Inst Sci LIPI, Res Ctr Chem, Kawasan Puspiptek Serpon 15314, Tangerang Selat, Indonesia
[2] Syarif Hidayatullah State Islamic Univ UIN Jakart, Fac Med & Hlth Sci, Program Study Pharm, Jakarta, Indonesia
来源：
INDONESIAN JOURNAL OF CHEMISTRY | 2015年 / 15卷 / 01期
关键词：
nitration; methyl trans-cinnamate; methyl 3-(2-nitrophenyl)acrylate; 3-(4-nitrophenyl)acrylate; P388 leukemia cells;
D O I：
10.22146/ijc.21226
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of methyl nitrophenyl acrylate via modification of methyl trans-cinnamate had been done to improve its biological activity. The reaction of methyl trans-cinnamate with nitrating agent gave methyl 3-(2-nitrophenyl)acrylate and methyl 3-(4-nitrophenyl)acrylate with an ortho/para ratio of 1:8. Its structure was confirmed with H-1-NMR, C-13-NMR, FTIR, GC-MS. Biological activity of methyl 3-(4-nitrophenyl) acrylate and methyl 3-(2-nitrophenyl)acrylate assays was performed on Cancer cells against P388 Murine Leukemia with IC50= 7.98 mu g/mL, IC50 = 27.78 mu g/mL.
引用
收藏
页码：70 / 76
页数：7
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