TIME-DEPENDENT ANTICONVULSANT ACTIVITY OF MELATONIN IN HAMSTERS

被引：56
|
作者：
GOLOMBEK, DA [1 ]
DUQUE, DF [1 ]
DE BRITO SANCHEZ, MG [1 ]
BURIN, L [1 ]
CARDINALI, DP [1 ]
机构：
[1] UNIV BUENOS AIRES, FAC MED, DEPT FISIOL, CC 243, RA-1425 BUENOS AIRES, ARGENTINA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 210卷 / 03期
关键词：
MELATONIN; CONVULSIONS; 3-MERCAPTOPROPIONIC ACID; BENZODIAZEPINE ANTAGONISM; (TIME-DEPENDENT EFFECTS);
D O I：
10.1016/0014-2999(92)90412-W
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of the present study was to assess whether the anticonvulsant activity of melatonin displays diurnal variability in hamsters. Convulsions were induced by administering 3-mercaptopropionic acid (3-MP). There was a significant diurnal variation in 3-MP-induced convulsions, hamsters being more prone to exhibit seizures during the night than during the day. Melatonin (50 mg/kg i.p.) had a maximal anticonvulsive effect in the early evening (20:00 h). The administration at 20:00 h of the central-type benzodiazepine antagonist, Ro 15-1788, although unable by itself to modify seizure threshold, blunted the anticonvulsant response to melatonin. The results indicate that the time-dependent anticonvulsant activity of melatonin is sensitive to central-type benzodiazepine antagonism.
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页码：253 / 258
页数：6
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