MUTATOR PLASMID IN A NALIDIXIC ACID-RESISTANT STRAIN OF SHIGELLA-DYSENTERIAE TYPE-1

被引：7
|
作者：
AMBLER, JE [1 ]
DRABU, YJ [1 ]
BLAKEMORE, PH [1 ]
PINNEY, RJ [1 ]
机构：
[1] N MIDDLESEX HOSP,DEPT MICROBIOL,LONDON N18 1QX,ENGLAND
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1993年 / 31卷 / 06期
关键词：
D O I：
10.1093/jac/31.6.831
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A clinical isolate of Shigella dysenteriae from Kashmir, resistant to seven antibacterial agents including nalidixic acid, carried four plasmids, only one of which was transferable by conjugation. This plasmid, designated pYD1, conferred trimethoprim resistance and increased the frequency of mutation to nalidixic acid resistance in recipient strains. Thus, although nalidixic acid resistance was not carried on a transferable plasmid, the presence of pYD1 increased the frequency at which the strain mutated to nalidixic acid resistance © 1993 The British Society for Antimicrobial Chemotherapy.
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页码：831 / 839
页数：9
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