One strategy which has been recommended for examining effects in repeated measures designs combines a degrees of freedom (d.f.)-adjusted univariate F test and a multivariate test. The results of a simulation study for a groups x trials repeated measures design are presented, and demonstrate that for balanced designs this combined strategy rarely provided superior Type I error control to that afforded by uniformly adopting either a univariate or multivariate test. For unbalanced repeated measures designs, all three strategies typically resulted in very conservative or very liberal Type I error rates when covariance matrices and group sizes were positively and negatively paired, respectively. For such designs, the approximate d.f. Welch-James (James, 1951, 1954; Welch, 1947, 1951) multivariate statistic developed by Johansen (1980) is preferable to any of the other strategies investigated in this paper. Power comparisons also favour the use of the Welch-James test.
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Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
Natl Heart Lung Blood Inst Framingham Heart Study, Framingham, MA USABoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
Yang, Qiong
Wu, Hongsheng
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Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
Wentworth Inst Technol, Dept Comp Sci, Boston, MA USABoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
Wu, Hongsheng
Guo, Chao-Yu
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Childrens Hosp Boston, Clin Res Program, Boston, MA USA
Childrens Hosp Boston, Program Genom, Boston, MA USA
Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USABoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA
Guo, Chao-Yu
Fox, Caroline S.
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Natl Heart Lung Blood Inst Framingham Heart Study, Framingham, MA USA
Brigham & Womens Hosp, Div Endocrinol Hypertens & Diabet, Boston, MA 02115 USABoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA