QUINOLONE COMPOUNDS WITH CARBOXYLIC EQUIVALENTS AND SEMIEMPIRICAL CALCULATIONS ON THEIR TAUTOMERS

被引：6
|
作者：
NAHM, K
KIM, WS
MOON, KY
机构：
[1] Specialty Chemicals, R and D Center, Science Town Dae-Jeon 305-343
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80730-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinolone antibiotic compounds having no carboxylic group but its equivalents at the 3-position have been synthesized. Energies of tautomers with the carboxylic mimics were calculated in gas phase and aqueous solution with AM1-SCRF method. Antibacterial activity of the compounds was rationalized with tautomeric protons and atomic charges of calculated tautomers.
引用
收藏
页码：2631 / 2634
页数：4
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