BIOTRANSFORMATIONS USING CLOSTRIDIA - STEREOSPECIFIC REDUCTIONS OF A BETA-KETO ESTER

被引：5
|
作者：
CHRISTEN, M
CROUT, DHG
HOLT, RA
MORRIS, JG
SIMON, H
机构：
[1] UNIV COLL WALES ABERYSTWYTH,DEPT BIOL SCI,ABERYSTWYTH SY23 3DA,DYFED,WALES
[2] TECH UNIV MUNICH,INST ORGAN CHEM,W-8046 GARCHING,GERMANY
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 04期
关键词：
D O I：
10.1039/p19920000491
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reduction of methyl 4-(4-chlorophenylthio)-3-oxobutanoate 1 by clostridia has been studied. Clostridium pasteurianum ATCC 6013, C. tyrobutyricum DSM 1460 and C. kluyveri NCIB 10680 gave the D-(3S) reduction product 2, whereas C. kluyveri DSM 555 gave the L-(3R) reduction product 3. The products could be obtained in higher optical purities than by yeast reductions.
引用
收藏
页码：491 / 493
页数：3
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