CLONING OF A GROWTH ARREST-SPECIFIC AND TRANSFORMING GROWTH-FACTOR BETA-REGULATED GENE, TI-1, FROM AN EPITHELIAL-CELL LINE

被引：47
|
作者：
KALLIN, B [1 ]
DEMARTIN, R [1 ]
ETZOLD, T [1 ]
SORRENTINO, V [1 ]
PHILIPSON, L [1 ]
机构：
[1] EUROPEAN MOLEC BIOL LAB, POSTFACH 10-2209, W-6900 HEIDELBERG, GERMANY
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 10期
关键词：
D O I：
10.1128/MCB.11.10.5338
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By cDNA cloning and differential screening, five genes that are regulated by transforming growth factor-beta (TGF-beta) in mink lung epithelial cells were identified. A novel membrane protein gene, TI 1, was identified which was downregulated by TGF-beta and serum in quiescent cells. In actively growing cells, the TI 1 gene is rapidly and transiently induced by TGF-beta, and it is overexpressed in the presence of protein synthesis inhibitors. It appears to be related to a family of transmembrane glycoproteins that are expressed on lymphocytes and tumor cells. The four other genes were all induced by TGF-beta and correspond to the genes of collagen alpha type I, fibronectin, plasminogen activator inhibitor 1, and the monocyte chemotactic cell-activating factor (JE gene) previously shown to be TGF-beta regulated.
引用
收藏
页码：5338 / 5345
页数：8
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