INTERLEUKIN-1, BUT NOT INTERLEUKIN-1 INHIBITOR, IS RELEASED FROM HUMAN MONOCYTES BY IMMUNE-COMPLEXES

被引：13
|
作者：
REMVIG, L
THOMSEN, BS
BAEK, L
SVENSON, M
BENDTZEN, K
机构：
[1] UNIV COPENHAGEN,RIGSHOSP,DEPT MED TTA,MED IMMUNOL LAB,DK-2100 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,RIGSHOSP,ENDOTOXIN LAB,DK-2100 COPENHAGEN,DENMARK
[3] UNIV COPENHAGEN,RIGSHOSP,DEPT INFECT DIS M,LYMPHOCYTE LAB,DK-2100 COPENHAGEN,DENMARK
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 32卷 / 03期
关键词：
D O I：
10.1111/j.1365-3083.1990.tb02918.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune complexes (IC) are believed to play a role in the pathogenesis of some autoimmune diseases in which interleukin 1 (IL‐1) and probably other cytokines also take part. This investigation shows that tetanus toxoid human anti‐tetanus toxoid IC induce human monocytes to release IL‐1. The activity was identified as being mainly IL‐1β by molecular size chromatography, isoelectric focusing, and anti‐IL‐1β affinity chromatography. Endotoxins were eliminated by repetitive washing of the IC suspension and by preincubation of IC with polymyxin B. The IL‐1‐inducing effect of IC was destroyed by healing at 80° C. and it was not blocked by the cytoskeleton inhibitor cytochalasin B. IL‐1 inhibitors were not detected in the supernatants. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：255 / 261
页数：7
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