MOLECULAR TARGET SIZE OF THE VANILLOID (CAPSAICIN) RECEPTOR IN PIG DORSAL-ROOT GANGLIA

被引：34
|
作者：
SZALLASI, A
BLUMBERG, PM
机构：
[1] Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda
来源：
LIFE SCIENCES | 1991年 / 48卷 / 19期
关键词：
D O I：
10.1016/0024-3205(91)90242-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The size of the vanilloid receptor was examined by high-energy radiation inactivation analysis of the binding of [H-3]resiniferatoxin to pig dorsal root ganglion membranes; it was found to be 270 +/- 25 kDa. This value most likely represents the size of a receptor complex rather than of an individual subunit. Other ligand-gated cation channel complexes have reported molecular weights in this range, e.g. 300 kDa for the acetylcholine receptor.
引用
收藏
页码：1863 / 1869
页数：7
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