Use of Molecular Markers for Cytologically Indeterminate Thyroid Nodules to Optimize Surgical Management

被引：0
|
作者：
Yip, Linwah [1 ]
机构：
[1] Univ Pittsburgh, Dept Surg, Div Endocrine Surg & Surg Oncol, Suite 101,3471 Fifth Ave, Pittsburgh, PA 15213 USA
来源：
CURRENT SURGERY REPORTS | 2014年 / 2卷 / 01期
关键词：
Thyroid nodule; Thyroid cancer; Thyroidectomy; Molecular markers; Mutation testing; Indeterminate biopsy; Surgical management; MicroRNA; Rearrangements;
D O I：
10.1007/s40137-013-0035-9
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The management of thyroid nodules with indeterminate cytology has traditionally been diagnostic thyroidectomy. However most nodules are benign, and for nodules that demonstrate histologic malignancy, two-stage thyroidectomy may be necessary. Molecular markers have emerged as an adjunct to preoperative FNAB cytology evaluation that can improve diagnostic accuracy. In this review, we discuss the latest methodologies and review diagnostic performance parameters of recent molecular marker techniques.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] Are Age and Sex Predictors of Malignancy in Cytologically Indeterminate Thyroid Nodules?
    Jafari, Pari
    Johnson, Daniel
    Cavallo, Allison
    Uraizee, Imran
    Vaghaiwalla, Tanaz
    Angelos, Peter
    Antic, Tatjana
    Cipriani, Nicole
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 377 - 378
  • [42] Role of Dynamic Markers in the Molecular Testing of Indeterminate Thyroid Nodules
    Banizs, Anna B.
    Toney, Nicole A.
    Jackson, Sara A.
    Narick, Christina M.
    Silverman, Jan E.
    Finkelstein, Sydney D.
    AJSP-REVIEWS AND REPORTS, 2019, 24 (01): : 9 - 12
  • [43] Utility of Diagnostic Molecular Markers for Evaluation of Indeterminate Thyroid Nodules
    Smith, Russell B.
    Ferris, Robert L.
    JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2016, 142 (05) : 421 - 422
  • [44] The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules
    Klubo-Gwiezdzinska, Joanna
    Wartofsky, Leonard
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (09): : 3507 - 3510
  • [45] Risk assessment of cytologically indeterminate thyroid nodules with integrated molecular testing and repeat biopsy: a surgical decision-oriented tool
    Xuhuizi Guan
    Tian Yu
    Zheng Zhang
    Lan Chen
    An Yan
    Yao Li
    Jiankun Li
    Dongdong Wang
    Jie Sun
    Feiliang Wang
    Gang Miao
    World Journal of Surgical Oncology, 21
  • [46] Current use of molecular profiling for indeterminate thyroid nodules
    Lopez Rojo, Irene
    Gomez Valdazo, Adela
    Gomez Ramirez, Joaquin
    CIRUGIA ESPANOLA, 2018, 96 (07): : 395 - 400
  • [47] Mutation Analysis Significantly Improves the Diagnostic Utility and Patient Management of Cytologically Indeterminate Thyroid Nodules
    Talwalkar, S. S.
    Lindeman, T.
    Green, S.
    Sizemore, J.
    Bany, J.
    Eskildsen, L.
    Edwards, K.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2015, 17 (06): : 842 - 842
  • [48] Risk assessment of cytologically indeterminate thyroid nodules with integrated molecular testing and repeat biopsy: a surgical decision-oriented tool
    Guan, Xuhuizi
    Yu, Tian
    Zhang, Zheng
    Chen, Lan
    Yan, An
    Li, Yao
    Li, Jiankun
    Wang, Dongdong
    Sun, Jie
    Wang, Feiliang
    Miao, Gang
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2023, 21 (01)
  • [49] Digital Gene Expression Profiling of a Series of Cytologically Indeterminate Thyroid Nodules
    Giannini, Riccardo
    Torregrossa, Liborio
    Gottardi, Stefano
    Fregoli, Lorenzo
    Borrelli, Nicla
    Savino, Mauro
    Macerola, Elisabetta
    Vitti, Paolo
    Miccoli, Paolo
    Basolo, Fulvio
    CANCER CYTOPATHOLOGY, 2015, 123 (08) : 461 - 470
  • [50] Role of frozen section in the surgical management of indeterminate thyroid nodules
    Najah, Haythem
    Tresallet, Christophe
    GLAND SURGERY, 2019, 8 : S112 - S117
12345