DIFFERENTIAL-EFFECTS OF CALCIUM-CHANNEL ANTAGONISTS ON TITYUSTOXIN AND OUABAIN-INDUCED RELEASE OF [H-3] ACETYLCHOLINE FROM BRAIN CORTICAL SLICES

被引：23

作者：

CASALI, TAA

GOMEZ, RS

MORAESSANTOS, T

GOMEZ, MV

机构：

[1] UFMG BELO,ICB,DEPT FARMACOL,GERAIS,BRAZIL

[2] UFMG BELO,FAC MED,DEPT CIRURG,GERAIS,BRAZIL

[3] UFMG BELO,FAC FARM,DEPT ALIMENTOS,GERAIS,BRAZIL

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 06期

关键词：

TITYUSTOXIN; OUABAIN; CALCIUM CHANNEL ANTAGONISTS; ACETYLCHOLINE OMEGA-CONOTOXINS; OMEGA-CONOTOXIN MVIIC; OMEGA-AGAIVA;

D O I：

10.1016/0028-3908(95)00019-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this paper, the effect of calcium channel blockers on acetylcholine release induced by tityustoxin and ouabain in rat brain cortical slices is described. Cadmium, a non-specific blocker of calcium channels, inhibited the release of ACh induced by tityustoxin. L-type calcium channel blockers (verapamil, nifedipine and diltiazen) had no effect on the release of ACh induced by tityustoxin. The release of ACh was also unaffected by nickel, a T-type calcium channel blocker, and the conotoxins GVIA and MVIIC, blockers of N and Q-type calcium channels. Agatoxin IVA, a specific blocker of the P-type calcium channel, inhibited the release of ACh induced by tityustoxin by 50%. The spontaneous release of ACh as well as ouabain-induced release of ACh was unaffected by any of the calcium channel blockers studied. It is concluded that ACh release induced by tityustoxin is mediated by Ca2+ influx via P-type calcium channels.

引用

页码：599 / 603

页数：5

共 50 条

[31] THE EFFECT OF 2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL (AH-5183), TITYUSTOXIN AND OUABAIN ON THE RELEASE OF ACETYLCHOLINE AND ITS MOBILIZATION FROM CYTOPLASMIC AND VESICULAR POOLS OF RAT-BRAIN CORTICAL SLICES
PRADO, MAM
SANTOS, TM
GOMEZ, MV
[J]. NEUROSCIENCE LETTERS, 1990, 111 (1-2) : 195 - 200
[32] THE PURPORTED DOPAMINE AGONIST DPI INHIBITS [NORADRENALINE-H-3 RELEASE FROM RAT CORTICAL SLICES BUT NOT [H-3]DOPAMINE AND [ACETYLCHOLINE-C-14 RELEASE FROM RAT STRIATAL SLICES INVITRO
VANOENE, JC
SMINIA, P
MULDER, AH
HORN, AS
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (12) : 786 - 792
[33] HP-749 ENHANCES CALCIUM-INDEPENDENT RELEASE OF [H-3] NOREPINEPHRINE FROM RAT CORTICAL SLICES AND SYNAPTOSOMES
SMITH, CP
HUGER, FP
PETKO, W
KONGSAMUT, S
[J]. NEUROCHEMICAL RESEARCH, 1994, 19 (10) : 1265 - 1270
[34] [H-3]-LABELED NORADRENALINE RELEASE FROM BRAIN-SLICES INDUCED BY AN INCREASE IN THE INTRACELLULAR SODIUM CONCENTRATION - ROLE OF INTRACELLULAR CALCIUM STORES
SCHOFFELMEER, ANM
MULDER, AH
[J]. JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) : 615 - 621
[35] MORPHINE WITHDRAWAL IN CORTICAL SLICES - SUPPRESSION BY CA-2+-CHANNEL INHIBITORS OF ABSTINENCE-INDUCED [H-3]-NORADRENALINE RELEASE
PELLEGRINIGIAMPIETRO, DE
BACCIOTTINI, L
CARLA, V
MORONI, F
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (03) : 535 - 540
[36] EFFECTS OF BETA-1 AND BETA-2 SELECTIVE ADRENERGIC AGONISTS AND ANTAGONISTS ON H-3 NE RELEASE FROM BRAIN-SLICES
MURUGAIAH, KD
ODONNELL, JM
[J]. FASEB JOURNAL, 1995, 9 (03): : A371 - A371
[37] TRANSMITTER-MEDIATED EFFECTS ON D-[H-3]ASPARTATE RELEASE FROM RAT CEREBRAL CORTICAL SLICES
NEVILLE, LF
ROBERTS, PJ
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1986, 14 (06) : 1144 - 1144
[38] TRANSMITTER-MEDIATED EFFECTS ON D-[H-3]ASPARTATE RELEASE FROM RAT CEREBRAL CORTICAL SLICES
NEVILLE, LF
ROBERTS, PJ
[J]. BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1986, 367 (11): : 1117 - 1117
[39] EFFECT OF PERMANENTLY CHARGED AND UNCHARGED DOPAMINERGIC AGONISTS ON THE POTASSIUM-INDUCED RELEASE OF [H-3] ACETYLCHOLINE FROM STRIATAL SLICES
SABOL, B
BOLDRY, R
FAROOQUI, T
CHANG, YA
MILLER, D
URETSKY, N
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (10) : 1679 - 1685
[40] DIFFERENTIAL-EFFECTS OF METHYLMERCURIC CHLORIDE AND MERCURIC-CHLORIDE ON THE L-GLUTAMATE AND POTASSIUM EVOKED RELEASE OF [H-3] DOPAMINE FROM MOUSE STRIATAL SLICES
MCKAY, SJ
REYNOLDS, JN
RACZ, WJ
[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1986, 64 (05) : 656 - 660

← 1 2 3 4 5 →