2 NEW INBRED RAT STRAINS DERIVED FROM SHR - WKHA, HYPERACTIVE, AND WKHT, HYPERTENSIVE, RATS

被引:87
|
作者
HENDLEY, ED
OHLSSON, WG
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 02期
关键词
GENETIC MODELS; VENTRICULAR HYPERTROPHY; HABITUATION; SPONTANEOUSLY HYPERTENSIVE RAT; RAT BEHAVIOR; CARDIOVASCULAR SYSTEM;
D O I
10.1152/ajpheart.1991.261.2.H583
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Two new strains of inbred rats have been developed. One, WKHA, exhibits hyperactivity, and the other, WKHT, exhibits hypertension. Both of these traits are expressed in the SHR. By crossing spontaneously hypertensive rats (SHRs) with Wistar-Kyoto (WKY) controls, followed by recombinant selected inbreeding, we succeeded in genetically separating the hyperactivity from the hypertension in two new strains. Longitudinal studies indicate a persistence of hypertension without hyperactivity in WKHTs, and hyperactivity without hypertension in WKHAs, over at least 1 year. Ventricular enlargement, another characteristic of SHRs, was observed in adult WKHTs after the onset of hypertension; however, ventricles were already enlarged in normotensive WKHAs at 6 wk. The emergent behavioral profile of WKHAs indicates that they retain the hyperactivity trait and hyper-reactivity to stress, and not some of the other behaviors of SHRs, such as poor habituation. Studies in WKHTs suggest that they are an improvement over SHRs as a model of genetic hypertension as they lack some prominent behavioral abnormalities. Nevertheless, the four genetically related strains (WKHA, WKHT, SHR, and WKY), used together, are considered most appropriate for seeking correlations of biological differences with either hypertension or hyperactivity.
引用
收藏
页码:H583 / H589
页数:7
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