A genetic linkage map of the rat derived from recombinant inbred strains

被引：101
|
作者：
Pravenec, M
Gauguier, D
Schott, JJ
Buard, J
Kren, V
Bila, V
Szpirer, C
Szpirer, J
Wang, JM
Huang, H
StLezin, E
Spence, MA
Flodman, P
Printz, M
Lathrop, GM
Vergnaud, G
Kurtz, TW
机构：
[1] CTR ETUD BOUCHET,GENET MOLEC LAB,F-91710 VERT LE PETIT,FRANCE
[2] WELLCOME TRUST CTR HUMAN GENET,OXFORD,ENGLAND
[3] INST BIOL,LAB GENET ESPECES,NANTES,FRANCE
[4] CHARLES UNIV,DEPT BIOL,FAC MED 1,PRAGUE,CZECH REPUBLIC
[5] FREE UNIV BRUSSELS,DEPT BIOL MOLEC,B-1640 RHODE ST GENESE,BELGIUM
[6] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143
[7] UNIV CALIF SAN DIEGO,DEPT PHARMACOL,SAN DIEGO,CA 92103
[8] UNIV CALIF IRVINE,DEPT PEDIAT,IRVINE,CA 92717
[9] HOP ST LOUIS,INSERM U358,PARIS,FRANCE
来源：
MAMMALIAN GENOME | 1996年 / 7卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1007/s003359900031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.
引用
收藏
页码：117 / 127
页数：11
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