CO-STORAGE IN LARGE DENSE-CORE VESICLES OF DOPAMINE AND CHOLECYSTOKININ IN RAT STRIATUM

被引：2
|
作者：
LLONA, I
ANNAERT, WG
JACOB, W
DEPOTTER, WP
机构：
[1] UNIV ANTWERP,DEPT MED,NEUROPHARMACOL & NEUROBIOL LAB,B-2610 ANTWERP,BELGIUM
[2] UNIV ANTWERP,DEPT MED,ELECTRON MICROSCOPY LAB,B-2610 ANTWERP,BELGIUM
来源：
NEUROCHEMISTRY INTERNATIONAL | 1994年 / 25卷 / 06期
关键词：
D O I：
10.1016/0197-0186(94)90156-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The subcellular localization of cholecystokinin in the striatum-an area where a high density of cholecystokinin containing terminals has been demonstrated-was studied using biochemical techniques. Cholecystokinin containing Vesicles were partially purified using iso-osmotic Ficoll gradients. As judged from their size and their buoyant density in isopycnic gradients, cholecystokinin containing vesicles represent large 'dense-core' vesicles. Negative staining and subsequent immunolabelling for synaptophysin at the electron microscopical level, showed labelled vesicles of 50-70 nm. Binding of dihydrotetrabenazine was detected in the cholecystokinin containing fractions. The results suggest that dopamine is co-stored with cholecystokinin in large dense vesicles in rat striatum.
引用
收藏
页码：573 / 581
页数：9
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