STRUCTURE OF 5-[1-(DIAMINOMETHYLENEHYDRAZONO)ETHYL]-4-METHYL-2-METHYLTHIOPYRIMIDINE

被引:2
|
作者
COUSSON, A
NECTOUX, F
BACHET, B
KOKEL, B
HUBERTHABART, M
机构
[1] INST CURIE,PHYS & CHIM SECT,CNRS,URA 448,F-75231 PARIS 05,FRANCE
[2] UNIV PARIS 06,MINERAL & CRISTALLOG LAB,CNRS,LA 09,F-75230 PARIS 05,FRANCE
[3] INST CURIE,INSERM,PHYS & CHIM SECT,F-75231 PARIS 05,FRANCE
关键词
D O I
10.1107/S0108270193002367
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The detailed structure of the title compound (5-acetyl-4-methyl-2-methylthiopyrimidine diaminomethylenehydrazone) revealed distinct differences between it and its already published dichloride salt. It is obviously characterized by its diaminomethylenehydrazono chain and the more symmetrical pyrimidine ring. This observation helps in understanding the chemical behavior of the molecule and sheds more light on the possible mechanism of action of antitumor drugs such as mitoguazone.
引用
收藏
页码:1670 / 1673
页数:4
相关论文
共 50 条
  • [21] Enantiomeric Separation and Thermodynamic investigation of (R)-5-[1-(4-Nitrobenzylsulfonyloxy)-ethyl]-5-(pyridine-2-yl)- [1,3,4]-thiadiazole, a Key Intermediate of Nafithromycin
    Rane, Vipul P. P.
    Ahirrao, Vinod K. K.
    Patil, Kiran R. R.
    Jadhav, Rajiv A. A.
    Ingle, Rahul G. G.
    More, Kiran B. B.
    Yeole, Ravindra D. D.
    ANALYTICAL CHEMISTRY LETTERS, 2019, 9 (05) : 625 - 633
  • [22] STRUCTURE OF 5-(1-METHYL-4-PIPERAZINYL)-[2,3-B][1,5]PYRIDO BENZOTHIAZEPINE
    SBIT, M
    DUPONT, L
    DIDEBERG, O
    LIEGEOIS, JF
    DELARGE, J
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1988, 44 : 319 - 321
  • [23] (S)-N-{1-[5-(4-Chlorobenzylsulfanyl)-1,3,4-oxadiazol-2-yl]ethyl}-4-methylbenzenesulfonamide
    Syed, Tayyaba
    Hameed, Shahid
    Jones, Peter G.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2793 - +
  • [24] 1-{1-[(2-Chlorothiazol-5-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone
    Chen, Xiao-Bao
    Tian, Jia-Hua
    Xu, Jing
    Yu, Yong
    Wang, Qun
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2840 - U1645
  • [25] Synthesis and properties of ethyl 1-aryl-5-methyl-4-[1-(phenylhydrazinylidene)ethyl]-1H-pyrazole-3-carboxylates
    M. A. Potopnyk
    V. S. Matiichuk
    M. D. Obushak
    Russian Journal of Organic Chemistry, 2017, 53 : 62 - 65
  • [26] 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid
    Wang, Wei
    Fang, Zheng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O2413 - U3064
  • [27] Synthesis and Properties of Ethyl 1-Aryl-5-methyl4-[1-(phenylhydrazinylidene)ethyl]-1H-pyrazole-3-carboxylates
    Potopnyk, M. A.
    Matiichuk, V. S.
    Obushak, M. D.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 53 (01) : 62 - 65
  • [28] Ethyl 5-(triphenylphosphoranylidene)-1,2,3-thiadiazole-4-carboxylate
    Liu, Ming-Guo
    Hu, Yang-Gen
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : O3206 - O3208
  • [29] PYRIMIDINES .2. NUCLEOPHILIC SUBSTITUTION REACTIONS OF ETHYL 4-CHLORO-2-METHYLTHIOPYRIMIDINE-5-CARBOXYLATE
    SHADBOLT, RS
    ULBRICHT, TL
    JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (13): : 1172 - &
  • [30] Ethyl 5-[(4,6-dimethoxypyrimidin-2-yl)ureido-sulfonyl]-1-methyl-1H-pyrazole-4-carboxylate
    Chopra, D
    Mohan, TP
    Rao, KS
    Row, TNG
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 : O2418 - O2420