GLYCINE BLOCKS THE PRESSOR-RESPONSE TO L-GLUTAMATE MICROINJECTED INTO THE NUCLEUS-TRACTUS-SOLITARII OF CONSCIOUS RATS

被引：0

作者：

MAUAD, H ^{[1
]}

COLOMBARI, E ^{[1
]}

BONAGAMBA, LGH ^{[1
]}

MACHADO, BH ^{[1
]}

机构：

[1] UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FISIOL,BR-14049900 RIBEIRAO PRET,BRAZIL

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 1995年 / 28卷 / 06期

关键词：

BARORECEPTOR REFLEX; EXCITATORY AMINO ACID; INHIBITORY AMINO ACID; CARDIOVASCULAR REGULATION; NEUROTRANSMITTER;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microinjection of L-glutamate into the nucleus tractus solitarii (NTS) of conscious freely moving Wistar rats (240-260 g) produces presser (+48 +/- 4 mmHg) and bradycardic (-153 +/- 20 bpm) responses. In the present study L-glutamate (2.5 nmol/100 nl) was microinjected before and after microinjection of increasing doses of glycine (10, 25 and 50 nmol/100 nl, N = 6) or saline (vehicle/100 nl, N = 6) into the NTS. Microinjections of increasing doses of glycine into the NTS produced a dose-dependent reduction in the presser but not in the bradycardic responses to L-glutamate. [10 nmol (+29 +/- 5 mmHg and -110 +/- 18 bpm), 25 nmol (+12 +/- 7 mmHg and -88 +/- 21 bpm) and 50 nmol (+4 +/- 2 mmHg and -100 +/- 31 bpm)] The dose-dependent blockade of the presser response to L-glutamate by glycine suggests an inhibitory neuromodulatory role for this amino acid in the sympatho-excitatory activity produced by L-glutamate microinjection into the NTS.

引用

页码：699 / 704

页数：6

共 41 条

[31] SUBSTANCE-P MICROINJECTIONS INTO THE NUCLEUS TRACTUS SOLITARIUS ELICIT A PRESSOR-RESPONSE IN CAPSAICIN-TREATED RATS
CARTER, DA
LIGHTMAN, SL
NEUROSCIENCE LETTERS, 1983, 43 (2-3) : 253 - 257
[32] Cardiovascular and sympathetic effects of L-glutamate and glycine injected into the rostral ventrolateral medulla of conscious rats
Sakima, A
Yamazato, M
Sesoko, S
Muratani, H
Fukiyama, K
HYPERTENSION RESEARCH, 2000, 23 (06) : 633 - 641
[33] ALTERED TONIC L-3,4-DIHYDROXYPHENYLALANINE SYSTEMS IN THE NUCLEUS-TRACTUS-SOLITARII AND THE ROSTRAL VENTROLATERAL MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
YUE, JL
OKUMURA, Y
MIYAMAE, T
UEDA, H
MISU, Y
NEUROSCIENCE, 1995, 67 (01) : 95 - 106
[34] Blockade of the commNTS neurons reduces the pressor response induced by L-glutamate injected into the caudal pressor area in anesthetized rats
Takakura, ACT
Campos, RR
Menani, JV
Moreira, TS
Colombari, E
FASEB JOURNAL, 2005, 19 (04): : A596 - A597
[35] Role of carbon monoxide in L-glutamate-induced cardiovascular responses in nucleus tractus solitarius of conscious rats
Silva, CCS
Almeida, VA
Haibara, AS
Johnson, RA
Colombari, E
BRAIN RESEARCH, 1999, 824 (02) : 147 - 152
[36] Blockade of Gamma-Aminobutyric Acid Synthesis within the Nucleus Tractus Solitarii Reduces the Pressor Response to Muscle Mechanoreflex Activation in Normotensive but not Hypertensive Rats
Downey, Ryan M.
Mizuno, Masaki
Mitchell, Jere H.
Smiths, Scott A.
FASEB JOURNAL, 2016, 30
[37] Maternal protein restriction affects cardiovascular, but not respiratory response to L-glutamate microinjection into the NTS of conscious rats
Alves, D. S.
Barbosa, D. F. S.
Nogueira, V. O.
Tourneur, Y.
Fontes, D. A. F.
Brito-Alves, L.
Costa-Silva, J. H.
NUTRITIONAL NEUROSCIENCE, 2021, 24 (11) : 907 - 918
[38] BARORECEPTOR-AORTIC NERVE-MEDIATED RELEASE OF ENDOGENOUS L-3,4-DIHYDROXYPHENYLALANINE AND ITS TONIC DEPRESSOR FUNCTION IN THE NUCLEUS-TRACTUS-SOLITARII OF RATS
YUE, JL
OKAMURA, H
GOSHIMA, Y
NAKAMURA, S
GEFFARD, M
MISU, Y
NEUROSCIENCE, 1994, 62 (01) : 145 - 161
[39] GABA may function tonically via GABAA receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats
Honjo, K
Goshima, Y
Miyamae, T
Misu, Y
NEUROSCIENCE LETTERS, 1999, 261 (1-2) : 93 - 96
[40] Role of GABAa receptors in the nucleus of the solitary tract (NTS) on the cardiovascular responses induced by L-glutamate (L-glu) in conscious rats
Sato, MA
Dias, FM
Gonçalves, PPL
Colombari, E
FASEB JOURNAL, 2000, 14 (04): : A64 - A64

← 1 2 3 4 5 →