APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY IS NOT INCREASED IN PROGRESSIVE SUPRANUCLEAR PALSY

被引：41
|
作者：
TABATON, M
ROLLERI, M
MASTURZO, P
CAMMARATA, S
ANGELINI, G
HANSEN, LA
SAITOH, T
PETERSON, RB
PERRY, G
RICHEY, P
GAMBETTI, P
BERTOLINI, S
机构：
[1] UNIV GENOA,DEPT INTERNAL MED,CTR ATHEROSCLEROSIS PREVENT,I-16132 GENOA,ITALY
[2] NATL INST CANC RES,GENOA,ITALY
[3] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106
[4] UNIV CALIF SAN DIEGO,DEPT NEUROCIENCIES,SAN DIEGO,CA
来源：
NEUROLOGY | 1995年 / 45卷 / 09期
关键词：
D O I：
10.1212/WNL.45.9.1764
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE is an element of 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.
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收藏
页码：1764 / 1765
页数：2
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