APOLIPOPROTEIN-E EPSILON-4 ALLELE IN ALZHEIMERS-DISEASE AND VASCULAR DEMENTIA

被引：128

作者：

FRISONI, GB

CALABRESI, L

GEROLDI, C

BIANCHETTI, A

DACQUARICA, AL

GOVONI, S

SIRTORI, CR

TRABUCCHI, M

FRANCESCHINI, G

机构：

[1] IST S CUORE FBF,ALZHEIMERS DIS UNIT,BRESCIA,ITALY

[2] UNIV MILAN,CTR E GROSSI PAOLETTI,MILAN,ITALY

[3] UNIV MILAN,INST PHARMACOL SCI,MILAN,ITALY

来源：

DEMENTIA | 1994年 / 5卷 / 05期

关键词：

ALZHEIMERS DISEASE; VASCULAR DEMENTIA; DEMENTIA OF FRONTAL TYPE; APOLIPOPROTEIN E;

D O I：

10.1159/000106730

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The frequency of the epsilon 4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer's disease, but its prevalence in non-Alzheimer dementias in Caucasian populations is unknown. We found that the frequency of the apoE epsilon 4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly controls. The association of apoE epsilon 4 allele is not unique to Alzheimer's disease, and its importance as a risk factor for the disease should be reconsidered.

引用

页码：240 / 242

页数：3

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