POSSIBLE MECHANISMS OF CHROMOSOMAL-ABERRATIONS .7. COMPARATIVE DYNAMICS OF SISTER-CHROMATID DISJUNCTION AND REALIZATION OF RADIATION-INDUCED CHROMOSOMAL-ABERRATIONS DURING MITOSIS

被引：0

作者：

LEBEDEVA, LI

AKHMAMETEVA, EM

机构：

来源：

GENETIKA | 1994年 / 30卷 / 05期

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D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An increase in radiation-induced chromosomal aberrations during c-metaphase sister chromatid disjunction was demonstrated in murine bone marrow cells exposed to a total gamma-irradiation at 0.5 and 1.5 Gy. Caffeine (Cf) treatment during mitosis partially suppressed of the chromatid disjunction rate and increased the number of radiation-induced aberrations in this mitosis. Nalidixic acid (NA) treatment of c-metaphase cells completely suppressed chromatid disjunction and the realization of induced aberrations. Topoisomerase 2 was assumed to be involved during mitosis in both processes.

引用

页码：644 / 648

页数：5

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