POSSIBLE MECHANISMS OF CHROMOSOMAL-ABERRATIONS .7. COMPARATIVE DYNAMICS OF SISTER-CHROMATID DISJUNCTION AND REALIZATION OF RADIATION-INDUCED CHROMOSOMAL-ABERRATIONS DURING MITOSIS

被引：0
|
作者：
LEBEDEVA, LI
AKHMAMETEVA, EM
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来源：
GENETIKA | 1994年 / 30卷 / 05期
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中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
An increase in radiation-induced chromosomal aberrations during c-metaphase sister chromatid disjunction was demonstrated in murine bone marrow cells exposed to a total gamma-irradiation at 0.5 and 1.5 Gy. Caffeine (Cf) treatment during mitosis partially suppressed of the chromatid disjunction rate and increased the number of radiation-induced aberrations in this mitosis. Nalidixic acid (NA) treatment of c-metaphase cells completely suppressed chromatid disjunction and the realization of induced aberrations. Topoisomerase 2 was assumed to be involved during mitosis in both processes.
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页码：644 / 648
页数：5
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