PHENOTYPIC ANALYSIS OF T-LYMPHOCYTES DERIVED FROM TUMOR-INFILTRATING LYMPHOCYTES AND PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN PATIENTS WITH RENAL-CELL CARCINOMA

被引：0

作者：

ROZNOWSKI, A ^{[1
]}

BANAT, G ^{[1
]}

KABELITZ, D ^{[1
]}

STAEHLER, G ^{[1
]}

POMER, S ^{[1
]}

机构：

[1] UNIV KLIN HEIDELBERG, INST IMMUNOL, D-69120 HEIDELBERG, GERMANY

来源：

TUMORDIAGNOSTIK & THERAPIE | 1994年 / 15卷 / 03期

关键词：

T-LYMPHOCYTES; TUMOR INFILTRATING LYMPHOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELLS; RENAL CELL CARCINOMA;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To study the distribution of T-lymphocytes in renal cell carcinoma, tumor-infiltrating lymphocytes (TIL) and peripheral blood mononuclear cells (PBMC) were analyzed in 31 untreated patients by two-colour flow cytometry using 33 monoclonal antibodies. T-cells from TIL and PBMC were different in CD4/CD8 ratio (1.1 vs. 2.5), and in values of activation markers: MHC-II+ (54% vs. 10 %), CD45Ro (81 % vs. 50 %), CD63 (36 % vs. 11 %) and CD69 (60 % vs. 2 %). There was a correlation between the decreasing grading and the expression of CD8, CD25, CD71 and VLA-1. However IL-2 receptor values were unexpectedly rather low (7 % vs. 4 %). The low levels of transferrine receptor (CD71) positive cells suggest an insignificant proliferation of T-lymphocytes despite their activation state. Natural killer cell markers were decreased in tumor infiltrates partly as a result of enzyme digestion, yet confirming their known deficiency in renal cell cancers.

引用

页码：89 / 95

页数：7

共 50 条

[41] Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients
Schondorf, T
Engel, H
Kurbacher, CM
Brenne, U
Kolhagen, H
Gohring, UJ
Scharl, A
Mallmann, P
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1998, 5 (02) : 102 - 107
[42] Gene expression profile of peripheral blood mononuclear cells may reflect those of tumor-infiltrating lymphocytes in hepatocellular carcinoma
Sakai, Yoshio
Honda, Masao
Fujinaga, Haruo
Tatsumi, Isamu
Kaneko, Shuichi
HEPATOLOGY, 2007, 46 (04) : 796A - 796A
[43] EFFECT OF INTERFERON THERAPY ON INDOMETHACIN-SENSITIVE IMMUNOREGULATION IN THE PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF RENAL-CELL CARCINOMA PATIENTS
BRAUN, DP
HARRIS, ZL
HARRIS, JE
SANDLER, S
KHANDEKAR, J
LOCKER, G
HAID, M
GORDON, L
SHAW, J
COBLEIGH, M
GALLAGHER, P
TAYLOR, SG
SHOWEL, J
BONOMI, PD
JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS, 1983, 2 (03): : 251 - 262
[44] GENERATION OF CYTOTOXIC T-LYMPHOCYTES FROM PERIPHERAL-BLOOD
MCKINNON, JG
LALANI, A
SY, L
BEAR, HD
SURGERY, 1993, 113 (05) : 536 - 540
[45] SUBPOPULATIONS OF B-LYMPHOCYTES AND T-LYMPHOCYTES IN PERIPHERAL-BLOOD OF RHEUMATOID PATIENTS
KOSAKA, S
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 122 (04): : 349 - 353
[46] Characteristics of dendritic cells and regulatory T-lymphocytes in the blood and tumor tissue in patients with renal cell carcinoma
Minarik, I.
Last'ovicka, J.
Budinsky, V.
Kawaciuk, I.
Bartunkova, J.
EUROPEAN UROLOGY SUPPLEMENTS, 2009, 8 (08) : 676 - 677
[47] INTERLEUKIN-7 ENHANCES THE PROLIFERATION AND EFFECTOR FUNCTION OF TUMOR-INFILTRATING LYMPHOCYTES FROM RENAL-CELL CARCINOMA
SICA, D
RAYMAN, P
STANLEY, J
EDINGER, M
TUBBS, RR
KLEIN, E
BUKOWSKI, R
FINKE, JH
INTERNATIONAL JOURNAL OF CANCER, 1993, 53 (06) : 941 - 947
[48] GENERATION OF CYTOTOXIC T-LYMPHOCYTES FROM PERIPHERAL-BLOOD OF LEUKEMIC PATIENTS
NOURI, AME
DOREY, E
DAVIS, CL
ROHATINER, A
LISTER, TA
OLIVER, RTD
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1993, 37 (01) : 47 - 53
[49] CYTOKINE PRODUCTION BY TUMOR-INFILTRATING MONONUCLEAR-CELLS (TIMNC), LYMPH-NODE CELLS (LNC) AND PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBMC) FROM PATIENTS WITH BREAST-CANCER
RUBBERT, A
PLATZER, E
MANGER, B
LANG, N
KALDEN, JR
IMMUNOBIOLOGY, 1988, 178 (1-2) : 41 - 41
[50] EXPRESSION OF AMINOPEPTIDASE N/CD13 IN TUMOR-INFILTRATING LYMPHOCYTES FROM HUMAN RENAL-CELL CARCINOMA
RIEMANN, D
GOHRING, B
LANGNER, J
IMMUNOLOGY LETTERS, 1994, 42 (1-2) : 19 - 23

← 1 2 3 4 5 →