HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants

被引：0
|
作者：
DeLorenzi, E [1 ]
Massolini, G [1 ]
Macchia, M [1 ]
Caccialanza, G [1 ]
机构：
[1] UNIV PISA,DEPT PHARMACEUT SCI,I-56100 PISA,ITALY
来源：
CHROMATOGRAPHIA | 1995年 / 41卷 / 11-12期
关键词：
column liquid chromatography; polyurethane degradation products; 2,4- and 2,6-toluendiamine; urine analysis; breast implants;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A reversed-phase HPLC method has been developed for the urinary determination of mutagenic 2,4- and 2,6-toluendiamines. These amines are degradation products of polyurethane, a material used to cover textured silicone breast implants. FMOC-Cl was used as fluorescent derivatising agent in order to obtain a limit of detection of 15 ng/ml in urine. Pre-treatment of urine samples was by liquid/liquid extraction and urine specimens of patients after surgury were analysed.
引用
收藏
页码：661 / 664
页数：4
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