TOXICITY OF SULFUR-CONTAINING-COMPOUNDS TO NEURONAL CELL-LINES

被引：31
|
作者：
PEAN, AR
PARSONS, RB
WARING, RH
WILLIAMS, AC
RAMSDEN, DB
机构：
[1] UNIV BIRMINGHAM,SCH BIOCHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[2] QUEEN ELIZABETH HOSP,DEPT CLIN NEUROL,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
[3] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 129卷
关键词：
MND/ALS; CYSTEINE; NEURONS; TOXICITY; RAT NEURONAL CELL LINE; HUMAN NEUROBLASTOMA CELL; CYSTEIC ACID; CYSTEINE SULFINIC ACID; TAURINE; HOMOCYSTEIC ACID; BETA-N-METHYLAMINO-L-ALANINE; BETA-N-OXALAMINO-L-ALANINE; SULFATE; SPORADIC AMYOTROPHIC LATERAL SCLEROSIS;
D O I：
10.1016/0022-510X(95)00078-G
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cysteine and its metabolites cysteine sulphinic acid (CSA) and taurine (TA) were shown to be toxic to human and rat neuronal cell lines. However, the mechanisms of action of CSA and TA appeared to be different. As MND/ALS patients have high plasma and CSF cysteine levels, they may have increased levels of neurotoxins in vivo, since cysteine was more toxic than CSA in the assay system used. Cysteic acid, homocysteic acid, BMAA and BOAA were also toxic to the cell lines used.
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页码：107 / 108
页数：2
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