Notch Signaling during Oogenesis in Drosophila melanogaster

被引：22
|
作者：
Xu, Jingxia [1 ,2 ]
Gridley, Thomas [3 ]
机构：
[1] Jackson Lab, Bar Harbor, ME 01609 USA
[2] Univ Maine, Dept Mol & Biomed Sci, Orono, ME 04469 USA
[3] Maine Med Ctr Res Inst, Ctr Mol Med, Scarborough, ME 04074 USA
来源：
GENETICS RESEARCH INTERNATIONAL | 2012年 / 2012卷
关键词：
D O I：
10.1155/2012/648207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism that is required for embryonic development, cell fate specification, and stem cell maintenance. Discovered and studied initially in Drosophila melanogaster, the Notch pathway is conserved and functionally active throughout the animal kingdom. In this paper, we summarize the biochemical mechanisms of Notch signaling and describe its role in regulating one particular developmental pathway, oogenesis in Drosophila.
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页数：10
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