COMPARATIVE-STUDY OF ERYTHROMYCIN, TROLEANDOMYCIN AND TYLOSIN ON THE RABBIT INTESTINE

被引：3
|
作者：
KOUNENIS, G
KOUTSOVITIPAPADOPOULOU, M
ELEZOGLOU, V
机构：
[1] Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1994年 / 8卷 / 02期
关键词：
ERYTHROMYCIN; TROLEANDOMYCIN; TYLOSIN; RABBIT INTESTINE;
D O I：
10.1111/j.1472-8206.1994.tb00794.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The macrolide antimicrobial agents, erythromycin, troleandomycin and tylosin were tested for their effect on isolated whole segments of the rabbit duodenum, jejunum, ileum and ascending colon, as well as on strips of the circular and longitudinal smooth muscle of the ascending colon. The 14-membered macrolides erythromycin and troleandomycin were found to possess a concentration-dependent contractile effect on the intestinal smooth muscle. The order of potency was: erythromycin > troleandomycin. The 16-membered macrolide tylosin was found to have a much weaker potency than erythromycin and troleandomycin. In addition, the circular smooth muscle of the ascending colon was found to be more sensitive to the compounds tested than the longitudinal smooth muscle.
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页码：173 / 177
页数：5
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