CAN LIFE-STYLE CHANGES REVERSE CORONARY HEART-DISEASE

被引：1382
|
作者：
ORNISH, D
BROWN, SE
SCHERWITZ, LW
BILLINGS, JH
ARMSTRONG, WT
PORTS, TA
MCLANAHAN, SM
KIRKEEIDE, RL
BRAND, RJ
GOULD, KL
机构：
[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PSYCHOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT MED,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,SCH DENT PUBL HLTH & HYG,SAN FRANCISCO,CA 94143
[4] PACIFIC PRESBYTERIAN MED CTR,CARDIAC CATHETERISAT LABS,SAUSALITO,CA 94965
[5] UNIV CALIF SAN FRANCISCO,SCH MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143
[6] INTEGRAL HLTH SERV INC,RICHMOND,VA
[7] UNIV TEXAS,SCH MED,CTR CARDIOVASC & IMAGING RES,HOUSTON,TX 77025
[8] UNIV CALIF BERKELEY,SCH PUBL HLTH,DEPT BIOMED & ENVIRONM HLTH SCI,BERKELEY,CA 94720
来源：
LANCET | 1990年 / 336卷 / 8708期
关键词：
D O I：
10.1016/0140-6736(90)91656-U
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In a prospective, randomised, controlled trial to determine whether comprehensive lifestyle changes affect coronary atherosclerosis after 1 year, 28 patients were assigned to an experimental group (low-fat vegetarian diet, stopping smoking, stress management training, and moderate exercise) and 20 to a usual-care control group. 195 coronary artery lesions were analysed by quantitative coronary angiography. The average percentage diameter stenosis regressed from 40·0 (SD 16·9)% to 37·8 (16·5)% in the experimental group yet progressed from 42·7 (15·5)% to 46·1 (18·5)% in the control group. When only lesions greater than 50% stenosed were analysed, the average percentage diameter stenosis regressed from 61·1 (8·8)% to 55·8 (11·0)% in the experimental group and progressed from 61·7 (9·5)% to 64·4 (16·3)% in the control group. Overall, 82% of experimental-group patients had an average change towards regression. Comprehensive lifestyle changes may be able to bring about regression of even severe coronary atherosclerosis after only 1 year, without use of lipid-lowering drugs. © 1990.
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页码：129 / 133
页数：5
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